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Examine the burden of disease of PsA

The prevalence of comorbidities in patients with PsA

PsA is frequently associated with comorbidities that could affect the disease outcome and can impact a patient’s daily functioning and quality of life.1,2 To optimize important patient outcomes, physicians should globally assess disease activity and consider the impact of comorbidities on management decisions.1

~70% of patients experience at least one comorbidity1,3
Up to 40% of patients have more than three comorbidities3

Common comorbidities in patients with PsA include:

Depression6 Cardiovascular disease6 Diabetes5 Fibromyalgia8 Osteoporosis6 Obesity4 Metabolic syndrome7 Depression6 Cardiovascular disease6 Diabetes5 Osteoporosis6 Fibromyalgia8 Obesity4 Metabolic syndrome7

LECTURE SERIES WITH DR. SAAKSHI KHATTRI

The art of assessing the multiple disease domains of PsA and common comorbidities

Join Dr. Khattri as she discusses the complexity of managing patients with PsA who are experiencing comorbidities and multiple-domain involvement, and why a multidisciplinary approach is needed.

Recognizing the total burden of disease of PsA

PsA has a negative impact on patients’ quality of life, across all disease domains. For example:

  • Patients with enthesitis and dactylitis report increased disability from reduced physical functioning, as well as increased sleep disturbances and fatigue6,9,10
  • Patients report itching at the location of skin involvement in psoriasis, and pain/swelling of joints as factors contributing the most to disease severity11
  • Nail disease and disfiguration have been associated with physical and emotional distress and decreased productivity at work6

The quality of life for patients with PsA is further reduced by experiencing clinical presentations across multiple disease domains, comorbidities, and increased disease severity.12

It is important to consider all aspects of disease activity when managing patients with PsA—from specific measures of the various disease domains to assessing the impact on a patient’s quality of life.1,2

Explore the disease outcome measures used for PsA in our exhibit

How can underlying causes of disease affect the burden to patients?

A deeper understanding of the pathological processes that cause certain disease manifestations may impact patients’ burden of disease.

Gaze upon the Gallery of Cytokines

NEXT EXHIBIT IN THE PSA TOUR

PsA outcomes

Explore different disease outcome measures and their importance in defining PsA disease activity in clinical practice.

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Clinical manifestations

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  1. Lubrano E, Scriffignano S, Belen Azuaga, A, et al. Impact of Comorbidities on Disease Activity, Patient Global Assessment, and Function in Psoriatic Arthritis: A Cross-Sectional Study. Rheumatol Ther. 2020;7:825-836. doi.org/10.1007/s40744-020-00229-0
  2. Gupta S, Syrimi Z, Hughes DM, et al. Comorbidities in psoriatic arthritis: a systematic review and meta-analysis. Rheumatol Int. 2021;41:275–284. doi.org/10.1007/s00296-020-047
  3. Husted JA, Thavaneswaran A, Chandran V, et al. Incremental effects of comorbidity on quality of life in patients with psoriatic arthritis. J Rheumatol. 2013;40(8):1349-1356. doi:10.3899/jrheum.121500
  4. Tam LS, Tomlinson B, Chu TT, et al. Cardiovascular risk profile of patients with psoriatic arthritis compared to controls--the role of inflammation. Rheumatology (Oxford). 2008;47(5):718-723. doi:10.1093/rheumatology/ken090
  5. Dal Bello G, Gisondi P, Idolazzi L, et al. Psoriatic arthritis and diabetes mellitus: a narrative review. Rheumatol Ther. 2020;7(2):271-285. doi:10.1007/s40744-020-00206-7
  6. Lee S, Mendelsohn A, Sarnes E. The burden of psoriatic arthritis: a literature review from a global health systems perspective. P T. 2010;35(12):680-689.
  7. Raychaudhuri SK, Chatterjee S, Nguyen C, et al. Increased prevalence of the metabolic syndrome in patients with psoriatic arthritis. Metab Syndr Relat Disord. 2010;8(4):331-334. doi:10.1089/met.2009.0124
  8. Magrey MN, Antonelli M, James N, et al. High frequency of fibromyalgia in patients with psoriatic arthritis: a pilot study. Arthritis. 2013;2013:762921. doi:10.1155/2013/762921
  9. Kaeley GS, Eder L, Aydin SZ, Gutierrez M, et al. Enthesitis: A hallmark of psoriatic arthritis. Semin Arthritis Rheum. 2018;48(1):35-43. doi:10.1016/j.semarthrit.2017.12.008
  10. Kavanaugh A, Helliwell P, Ritchlin CT. Psoriatic arthritis and burden of disease: patient perspectives from the population-based multinational assessment of psoriasis and psoriatic arthritis (MAPP) survey. Rheumatol Ther. 2016;3(1):91-102. doi:10.1007/s40744-016-0029-z
  11. Lebwohl MG, Bachelez H, Barker J, et al. Patient perspectives in the management of psoriasis: results from the population-based Multinational Assessment of Psoriasis and Psoriatic Arthritis Survey. J Am Acad Dermatol. 2014;70(5):871-881.e830. doi:10.1016/j.jaad.2013.12.018
  12. Ogdie A, Hur P, Liu M, et al. Effect of multidomain disease presentations on patients with psoriatic arthritis in the corrona psoriatic arthritis/spondyloarthritis registry. J Rheumatol. 2021;48(5):698-706. doi:10.3899/jrheum.200371